This paper highlights the performance of Rectangular Textile Antenna (RTA) and Hexagonal Textile Antenna (HTA) for bio-medical application using Denim as substrate. The main objective of this paper is to compare both RTA and HTA with respect to antenna parameters for similar design specifications. The parameters considered in the analysis using denim textile material as a substrate has relative permittivity(? =1.7), loss tangent (tan =0.025), and thickness (5mm). The width and length of RTA and HTA have been optimized in HFSS. The result shows that Return Loss Bandwidth (RLBW) of HTA i.e. 150MHz. (6.12%) is greater than RLBW of RTA i.e. 120MHz (4.9%).